5-MTHF Thorne



The most biologically active form of folate; an excellent source of folate for pregnant women; supports optimal cardiovascular and nerve function

Benefits: Foundational, Heart/Vessels, Mood
Size: 60 Capsules
Categories: ,



The body’s conversion of synthetic, inactive folic acid is a multi-step biochemical process that occurs in the intestines and liver. In the presence of intestinal or liver dysfunction this conversion may not be sufficient to meet the body’s needs. Furthermore, up to 60 percent of the Canadian population may have a genetic enzyme defect that makes it difficult for them to convert folic acid into active 5-MTHF. For these individuals and many others, 5-MTHF supplementation may be a more effective method of folate repletion.

In concert with vitamin B12, 5-MTHF functions as a methyl-group donor involved in the conversion of the amino acid homocysteine to methionine. Methyl-group donation is vital to many biochemical processes, including the synthesis of serotonin, melatonin, and DNA. 5-MTHF is also involved in production of the catecholamine neurotransmitters (dopamine, norepinephrine, epinephrine) and the production of beneficial nitric oxide in vascular endothelial cells, which promotes healthy blood vessel function.

Suggested Use:

Recommended Use or Purpose (Adults):
A factor in the maintenance of good health. Helps to form red blood cells. Helps to reduce the risk of neural tube defects when taken daily prior to becoming pregnant and during early pregnancy.

Recommended Dose:
Take 1 capsule daily or as recommended by your health professional. Supplement this product with 2.4 mcg/day of Vitamin B12.


Medicinal Ingredients:
Per Capsule:

Folate (Calcium L-5-Methyltetrahydrofolate) 1,000 mcg

Non-Medicinal Ingredients: Hypromellose (derived from Cellulose) capsule, Microcrystalline Cellulose, L-Leucine, and Silicon Dioxide.


Keep out of the reach of children. Do not use if security seal inside the cap is broken. Store tightly sealed in a cool, dry place.

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